Texas State's CLS Program is a 2 + 2 university-based program. Senior CLS students take their lecture/laboratory courses on campus and complete their clinical education assignments at the clinical affiliates which are within commuting distance of San Marcos. These affiliates include but are not limited to the following:

• Capital Medical Clinic, Austin
• PPD Pharmaco, Austin
• Blood and Tissue Center of Central Texas, Austin
• Clinical Pathology Laboratories, Austin
• St. David's North Austin Medical Center, Austin
• University Medical Center at Brackenridge, Austin
• Seton Medical Center, Austin
• Seton Northwest Hospital Austin
• Seton Southwest Hospital, Austin
• Department of State Health Services, Austin
• Texas Oncology PA, Austin
• St. David's Georgetown Hospital, Georgetown
• Seton-Edgar B. Davis Hospital, Luling
• Christus Santa Rosa Hospital-New Braunfels, New Braunfels
• St. David's Round Rock Medical Center, Round Rock
• Seton Medical Center-Williamson, Round Rock
• South Texas Blood and Tissue Center, San Antonio
• Christus Santa Rosa Health Care, San Antonio
• Southwest General Hospital, San Antonio
• Clinical Pathology Laboratories, San Antonio
• Central Texas Medical Center, San Marcos
• Guadalupe Regional Medical Center, Seguin
• Smithville Regional Hospital, Smithville