Although all BSRC students are trained clinically as "generalists," they are rotated through every type of clinical subspecialty found in the Austin and San Antonio area. As a result, students usually experience a "passion or bias" for a specific clinical area and wish to specialized in that clinical area. During the senior year, RC 4246, Respiratory Care Internship, is the course affords an opportunity for each student to focus on a clinical subspecialty area by gaining another 160 clinical clock hours in that specialty, along with a completed project in the related area. This permits the graduate therapist to market him/herself as a BSRC graduate with a clinical specialty in the chosen field. The clinical specialty internship has opened many doors for past graduates by placing them in clinical areas as an "intern" with job positions offered to them at the conclusion of their rotation.

Clinical internships may be established in any of the surrounding area hospitals or through any of the over 500 clinical affiliates throughout the State of Texas and the US. Clinical affiliations may even be established outside the US at a student's request. Subspecialty interests are left to student interests and any innovative new approach to a clinical internship may be submitted to the Chair and Director of Clinical Education for consideration. Specializations chosen by BSRC students in the past have included areas such as adult critical care, emergent critical care, pediatric intensive care, neonatal intensive care, pulmonary function testing, polysomnography, hyperbaric medicine, case management, pulmonary rehabilitation, management, education, homecare, durable medical equipment sales, biomedical research, brain/spinal cord specialty, international respiratory care and many others.