The Clinical Laboratory Science Program, formerly the Medical Technology Program, went through many name changes and degree changes. Degrees were awarded as a Bachelor of Science in Medical Technology with a major in Biology in 1973. In 1974, the degree was changed to a Bachelor of Science in Health Professions with a major in Medical Technology. In 1976, it became a Bachelor of Science in Medical Technology with a major in Medical Technology. In 1994 it underwent its final change to a Bachelor of Science in Clinical Laboratory Science with a major in Clinical Laboratory Science.

For the first thirteen years of the program, students completed their senior year of coursework in Temple, Texas, at the Allied Health Education Building in the Olin E. Teague Veterans Administration Center, and their clinical education at the Veterans Administration Hospital, Scott and White Clinic, and Kings Daughters Hospital. In 1988 the laboratory, faculty, and staff were relocated to San Marcos. Now students complete their courses on campus and their clinical education at affiliates in Central Texas. The Clinical Laboratory Science has graduated over 400 students with the first three in 1973.

The Clinical Laboratory Science Program has been accredited by the National Accrediting Agency for Clinical Laboratory Sciences since 1975. The program recently received a seven-year renewal of accreditation and will have its next site visit in 2012.

The first faculty member hired for the CLS Program was Dave Falleur, in 1974. In 1975, two more faculty were added to the program, Dr. Lou Caruana, and Philip Kostroun. Dr. Caruana recently retired as Professor Emeritus. Rodney Rohde joined the faculty in the Spring of 2002 to replace Dr. Caruana. Dale Dingley is an adjunct faculty member who has been teaching parasitology for the past 5 years. Margaret Young, M.D., Ph.D., has served as Medical Advisor for the program since 1988.